Anaphylactoid Reaction Induced by Nafamostat Mesilate in a Hemodialysis Patient

Cardiac arrest caused by nafamostat mesilate

A 65-year-old man was transferred from the Department of Vascular Surgery to Nephrology because of cardiac arrest during hemodialysis. He underwent incision and drainage for treatment of a buttock abscess. Nafamostat mesilate was used as an anticoagulant for hemodialysis to address bleeding from the incision and drainage site. Sudden cardiac arrest occurred after 15 minutes of dialysis. The pat...

Nafamostat Mesilate Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production

Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation in patients undergoing continuous renal replacement therapy and extra corporeal membrane oxygenation. Oxidative stress is an independent risk factor for atherosclerotic vascular disease and is associated with vas...

A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate.

To elucidate the mechanism of propofol-induced pain on injection, we performed several studies using nafamostat mesilate, a kallikrein inhibitor, or lidocaine. As both pretreatment and low-dose mixing with nafamostat produced the same effects on pain reduction, we used the latter method in the following experiments. Low-dose mixing had the same effect on injection pain as mixing with lidocaine....

Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate.

Cardiac arrest caused by nafamostat mesilate: Kounis syndrome in the dialysis room?

Nafamostat is a broad spectrum serine protease inhibitor with anticoagulant properties that is used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin without increasing the risk of major bleeding, in patients prone to bleeding. In the very interesting report published in this Journal [1] concerning a 65-yearold man with diabetic neuropathy who was subjected to buttock abs...